Which of the following does not contribute to the stability of tRNA?

A. Hydrogen bonding

B. Hydrophobic interactions

C. Base and sugar-phosphate backbone interaction

D. Base pairing

Explanation: Due to the negative charge of the tRNA backbone, it is unlikely for the molecule to have a hydrophobic nature. Thus, hydrophobic interactions do not play any role in the structural stability of the molecule. On the other hand, the other interactions such as the hydrogen bonding lead to base-pairing which leads to its classic clover leaf model.

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